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Open Position

Associate Director, Biochemistry and Biophysics

Full-time role based in Cambridge, MA (Req number: 15339)

Within every human cell, nature has engineered finely-tuned control mechanisms to correct imbalances caused by stress and disease and promote healing. At Hotspot Therapeutics, nature is inspiring us to create a wave of new medicines.

Through a proprietary technology platform, we are uncovering privileged allosteric sites used by nature to control proteins – called regulatory hotspots – that can be exploited through small molecule drug discovery. Regulatory hotspots are allowing sought-after targets to be drugged for the first time while delivering molecules with exquisite selectivity, unshifted in vivo potency and attractive drug-like properties.

HotSpot is supported by a syndicate of leading healthcare investors based in the US and Europe.

Your motivations

You are a highly motivated, creative and collaborative biochemist and have significant experience in biophysical screening methods. You want to play a critical role in leading pipeline program(s) and shaping HotSpot’s platform for new target identification.

You will be joining a seasoned team of drug hunters with an excellent track record in drug discovery. As a HotSpotter, you are comfortable thinking outside the box and breaking convention. You are curious about the world and contribute beyond your precise role description. You can think strategically in one moment but then roll your sleeves up to troubleshoot an experimental protocol in the next. You are action orientated and extraordinary at getting things done. You communicate openly with your colleagues and you hate office politics.

Your role

You will serve as the biology lead on a drug discovery program and will contribute as a team member to others.  We will look to you to continually develop HotSpot’s biochemical and biophysical capabilities in assay development, screening and mechanism of action elucidation.

Your typical day will involve:

  • Develop a deep understanding of target biology and become the ‘go to’ person for all related aspects
  • Manage a team of external contract research organization (CRO) scientists
  • Design and lead biochemical and/or biophysical mechanism-of-action studies using a variety of in vitro techniques
  • Initiate structural biology studies to elucidate the site of interaction
  • Coordinate protein production activities
  • Actively solicit input from experts to validate experimental design and interpret data
  • Establish academic collaborations to access information on biochemical and cell-based models not available through CROs
  • Work with translational science team to develop relevant biomarker strategies
  • You will play a key role assessing the output from HotSpot technology platform to identify our next pipeline targets

Your background

  • You have earned a PhD in biological sciences (biochemistry, mechanistic enzymology, molecular biophysics, or related) or another relevant degree
  • You have at least seven (7) years of relevant research experience in industryAt HotSpot, we have a bold mission to establish new drug discovery paradigm.

If this appeals to you, please let us know at iamcurious@hotspotthera.com.

HotSpot is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

At HotSpot, we have a bold mission to establish new drug discovery paradigm. If this appeals to you, please let us know at