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Computational Chemistry – Associate Research Fellow/Sr Scientist III

Full-time role based in Cambridge, MA


Computational Chemistry – Associate Research Fellow/Sr Scientist III

Within every human cell, nature has engineered finely-tuned control mechanisms to correct imbalances caused by stress and disease and promote healing.  At HotSpot Therapeutics, nature is inspiring us to create a wave of new medicines.

Through a proprietary technology platform, we are uncovering privileged allosteric sites used by nature to control proteins – called regulatory hotspots– that can be exploited through small molecule drug discovery.  Regulatory hotspots are allowing sought-after targets to be drugged for the first time while delivering molecules with exquisite selectivity and attractive drug-like properties.

HotSpot is supported by a syndicate of leading healthcare investors based in the US and Europe.

You will be joining a seasoned team of drug hunters with an excellent track record in drug discovery. As a HotSpotter, you are comfortable thinking outside the box and breaking convention.  You are curious about the world and contribute beyond your precise role description. You are action orientated and extraordinary at getting things done.  You communicate openly with your colleagues and you hate office politics.


Major Responsibilities:

  • Creating computational chemistry solutions for drug discovery projects
  • Developing structural hypotheses and supporting medicinal chemistry efforts
  • Interacting with experienced drug design team to develop novel compounds to enhance potency, selectivity and PK
  • Executing structure-based drug design for lead generation and lead optimization
  • Creating pharmacophore, homology, QSAR and other empirical models
  • Accessing and manipulating sequence, crystallographic data, and homology modeling

Requirements and Qualifications:

  • Ph.D. degree in computational chemistry, computational biology or a related field, with 8+ years of related work experience within a pharmaceutical or biotech environment
  • Strong familiarity with a wide range of current computational chemistry software suites from vendors like Schrodinger, OpenEye, CCG, Biovia and Molecular Discovery.
  • Proven track record as part of drug-discovery teams that successfully delivered clinical candidates is desirable
  • Expert molecular designer with creativity and the ability to design ligands & libraries; utilizes broad set of tools to evaluate/prioritize ideas.
  • Proven leadership experience managing projects; must be capable of building computational chemistry as a function within the organization
  • Excellent oral and written communication skills and organizational skills are essential
  • Good understanding of medicinal chemistry and basic knowledge of synthetic organic chemistry.
  • The ability to work independently as effectively as being able to collaborate in multidisciplinary teams.
  • Strong analytical and problem-solving skills and scientific creativity are essential.
  • Experience in one programming language C/C++/C#, Java or scripting in Perl/Python.

HotSpot is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

At HotSpot, we have a bold mission to establish new drug discovery paradigm. If this appeals to you, please let us know at: