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Open Position

Associate Scientist, DNA-Encoded Library Group

Full-time role based in Monmouth Junction, NJ

Within every human cell, nature has engineered finely tuned control mechanisms to correct imbalances caused by stress and disease and promote healing. At HotSpot Therapeutics, nature is inspiring us to create a wave of new medicines.

Through a proprietary technology platform, we are uncovering privileged allosteric sites used by nature to control proteins – called regulatory hotspots– that can be exploited through small molecule drug discovery. Regulatory hotspots are allowing sought-after targets to be drugged for the first time while delivering molecules with exquisite selectivity and attractive drug-like properties.

HotSpot is supported by a syndicate of leading healthcare investors based in the US and Europe. You will be joining a seasoned team of drug hunters with an excellent track record in drug discovery.  As a HotSpotter, you are comfortable thinking outside the box and breaking convention. You are curious about the world and contribute beyond your precise role description. You are action oriented and extraordinary at getting things done. You communicate openly with your colleagues and you hate office politics.

HotSpot is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

 

Mission:Produce High-Quality DNA-Encoded Libraries

Build and use our DNA-Encoded Library (DEL) platform.

 

Deliverables

Perform library design and build activities

  • Develop new chemistry to be used in future DEL builds
  • Perform the profiling of library inputs, includes other group members
  • Use SOPs, protocols, and other build documentation to ensure robust build quality
  • Perform DEL library build processes.
  • Follow-up chemistry to utilize the output of DEL screens
  • Work as a part of the HotSpot build team

 

Competencies

  • Chemistry background
  • Driven, self motivated without supervision; can define a clear process for achieving goal
  • Output oriented – rapidly commit thinking to slides
  • Open and collaborative worker/communicator who is comfortable operating in a team setting
  • Comfortable working within distributed team model including use of Zoom or other video-conference tools
  • Experience working with Microsoft Powerpoint, Word, and Excel
  • Ability to integrate data/input from different sources and team members
  • BS or MS with 0-4 years industry experience.
  • Synthetic chemistry/medicinal training.

 

If you are interested in this role, please email: