Nature tends to control the activity of proteins in the cell not through the active site but through allosteric regulatory sites. Hotspot is focused on finding modulators of these allosteric sites in well validated disease targets in order to drug proteins previously perceived hard to drug or undruggable.
Through a proprietary technology platform, we are uncovering privileged allosteric sites – called regulatory hotspots– that can be exploited for small molecule drug discovery. Regulatory hotspots are allowing sought-after targets to be drugged for the first time while delivering molecules with exquisite selectivity, in vivo potency and attractive drug-like properties.
HotSpot is supported by a syndicate of leading healthcare investors based in the US and Europe. For more information, please see our website at www.hotspotthera.com.
You are a highly motivated, creative and collaborative biologist and have significant experience in leading drug discovery projects in biotech or pharma. You want to play a critical role in advancing Hotspot’s allosteric drug discovery programs all the way into the clinic.
You will be joining a seasoned team of drug hunters with an excellent track record in drug discovery. As a HotSpotter, you are comfortable thinking outside the box and breaking convention. You are curious about the world and contribute beyond your precise role description. You can think strategically in one moment but then roll your sleeves up to troubleshoot an experimental protocol in the next. You are action oriented and extraordinary at getting things done. You communicate openly with your colleagues and you hate office politics.
You will serve as the biology project lead on an advancing drug discovery program and will contribute as a team member to others. Your responsibilities will include:
- Develop a deep understanding of target biology and become an expert on the target and the associated disease indications
- Design and lead biochemical and cellular mechanism-of-action studies using a variety of established and novel tools
- Coordinate all biological aspects around the target including protein production, structural biology, biochemical and cellular target engagement studies as well as the development of pharmacodynamic (PD) markers that can be used in cells and animal models
- Manage a team of external contract research organization (CRO) scientists
- Work with your counterpart in medicinal chemistry to interpret and communicate data, identify and push to solve hurdles for the program
- Establish in vivo models at CROs including PD, sub-chronic and chronic disease models
- Work with your counterpart in medicinal chemistry to establish a PK/PD/efficacy relationship for the target
- Actively solicit input from experts to validate experimental design and interpret data
- Establish academic collaborations to access information on biochemical, cell-based and in vivo models not available through CRO’s
- Work with Business Development & Strategy functions to define/refine the Target Candidate Profile (TCP) for the program
- You have earned a PhD in the biological sciences (biochemistry, molecular biology, pharmacology or other relevant area)
- You have a proven track record of scientific achievement illustrated in your list of publications
- You have at least seven (7) years of relevant research experience in the biotech or pharma industry, including project leadership experience