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Open Position

Director, Structural Biology

Full-time role based in Boston, MA

We are seeking a highly skilled and motivated structural biologist with extensive pharmaceutical industry experience to become an integral member of the HotSpot drug discovery team. The successful candidate will provide leadership and expertise in solving the structures of challenging targets in complex with ligands using appropriate methods including X-ray crystallography, NMR and cryo-EM.

Within every human cell, nature has engineered finely tuned control mechanisms to correct imbalances caused by stress and disease and promote healing. At HotSpot Therapeutics, nature is inspiring us to create a wave of new medicines.

Through a proprietary technology platform, we are uncovering privileged allosteric sites used by nature to control proteins – called regulatory hotspots– that can be exploited through small molecule drug discovery. Regulatory hotspots are allowing sought-after targets to be drugged for the first time while delivering molecules with exquisite selectivity and attractive drug-like properties.

HotSpot is supported by a syndicate of leading healthcare investors based in the US and Europe. You will be joining a seasoned team of drug hunters with an excellent track record in drug discovery. As a HotSpotter, you are comfortable thinking outside the box and breaking convention. You are curious about the world and contribute beyond your precise role description. You are action oriented and extraordinary at getting things done. You communicate openly with your colleagues and you hate office politics.

HotSpot is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

Key Responsibilities:

  • Effectivelyinteract with colleagues in cell biology, biochemistry and biophysics, computational and medicinal chemistry and other functional groups to solve project specific structural biology related problems to drive project progression
  • Design structural biology strategy for specific targets and determine apo and ligand bound structures using X-ray crystallography, NMR and cryo-EM techniques or other applicable technologies
  • Manage external CROs to ensure the delivery of high-quality protein structural information through efficient recombinant protein design, protein expression, protein purification, crystallization, co-crystal structure determination, data collection and refinement. Provide guidance for trouble shooting. Efficiently accomplish project goals on time and budget.
  • Stay scientifically current, and willingness to implement new technologies to the structure-based drug design process focusing on allosteric sites
  • Make intellectual contributions to all stages of the drug discovery process and clearly articulate deliverables, progress, and issues to drug discovery teams.


  • Ph.D. degree in structural biology or related discipline with 10+ years of industry experience
  • Proven ability to deliver structures for technically challenging proteins and ligand bound protein complexes, experience with kinases and proteins with allosteric sites are a plus
  • Extensive experience in solving protein structures using NMR, X-ray crystallography and cryo-EM
  • Experience balancing CRO and internal resources to solve problems and drive progress
  • Exceptional interpersonal and communication skills, and the ability to work seamlessly with multiple drug discovery teams and provide structure related support at all stages of the project
  • Demonstrated track record of success in structure-enabled drug discovery programs, as evidenced by a significant publication record in journals, patents and presentations
  • Strong interpersonal, influencing and collaboration skills to work in a team-oriented matrix environment, and the ability to work independentlyand effectively within tight timelines.
  • Strong organizational skills; ability to manage multiple projects simultaneously and the capability to prioritize
  • Ability and willingness to learn and adopt emerging technologies to drug discovery process
  • Ability to adapt to and effectively manage changes in a fast paced, dynamic environment
  • A passion for drug discovery and sense of urgency to find new medicines for patients



If you are interested in this role, please email: