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Open Position

Senior Manager, Accounting Operations

Full-time role based in Boston, MA

Within every human cell, nature has engineered finely tuned control mechanisms to correct imbalances caused by stress and disease and promote healing. At HotSpot Therapeutics, nature is inspiring us to create a wave of new medicines.

Through a proprietary technology platform, we are uncovering privileged allosteric sites used by nature to control proteins – called regulatory hotspots– that can be exploited through small molecule drug discovery. Regulatory hotspots are allowing sought-after targets to be drugged for the first time while delivering molecules with exquisite selectivity and attractive drug-like properties.

HotSpot is supported by a syndicate of leading healthcare investors based in the US and Europe. You will be joining a seasoned team of drug hunters with an excellent track record in drug discovery.  As a HotSpotter, you are comfortable thinking outside the box and breaking convention. You are curious about the world and contribute beyond your precise role description. You are action oriented and extraordinary at getting things done. You value open communication and collaboration you’re your colleagues.


Reporting to the Controller,  the Senior Manager, Accounting Operations will be a key contributor in building a dynamic accounting and finance organization dedicated to financial integrity and focused on supporting our growth strategy.


  • Manage the month end close process.
  • Review journal entries recorded in the general ledger system, which includes supporting documentation and work papers.
  • Assist with the annual budgeting and monitor budget to actual variances
  • Ensure assigned balance sheet and income statement reconciliations are completed timely
  • Manage the financial close process; from coordination and communication of the close calendar through delivery of financial results to all stakeholders.
  • Assist with the quarterly and annual process for filing the Form 10-Q and 10-K (Edgar and XBRL), including drafting and reviewing documents, ensuring quality while administering to strict timelines.
  • Ensure that the Company’s public financial statements and other SEC filings are of the highest standards of quality, GAAP compliant and useful to management and investors.
  • Manage annual process for filing the financial statements and Form 5500 for the Company’s 401K plan.
  • Assist with the implementation of the Company’s SOX compliance program, including design and initial testing of internal controls by an outside firm.
  • Ensure completeness and timelines of the Company’s SOX compliance documentation. 
  • Monitor the adequacy of design and the effectiveness of execution of the control framework to ensure that it sufficiently mitigates the risk over financial reporting operations, compliance, and information technology.
  • Update/implement accounting policies and procedures to respond to changes in the Company’s business, and SEC/GAAP regulations.  
  • Assist with the implementation of a new general ledger system (NetSuite) and other IT initiatives.
  • Identify process improvements and assist in the implementation of related processes and controls. 
  • Perform all other related duties as assigned.


The ideal candidate will be a motivated self-starter with a strong work ethic and the ability to work well in a team environment.  The position requires a deadline-driven individual with attention to detail who can handle confidential information sensitively.  

  • Strong accounting and financial leadership experience of 7+ years total experience, including significant time in public and/or operational accounting.
  • Experience in a development-stage biotechnology is highly preferred.
  • Experience with the SEC compliance issues of a public company.
  • Detailed knowledge of the Sarbanes-Oxley Act, including JOBS Act requirements, specifically Section 404, and an ability to drive the Company’s compliance with all relevant accounting and certification requirements.
  • Financial (IT) systems experience.
  • Aptitude for planning/managing deadlines.
  • Exceptional communication skills, including the ability to effectively present information to various levels of an organization. 
  • Strong commitment to a team approach and awareness of team and individual success dependencies.
  • Creative approach to problem solving and the ability to think “out-of the box.”
  • Ability to self-motivate and function independently, driven towards superior effort and performance and the desire to work in a very dynamic environment.


  • Bachelor’s degree in accounting or finance
  • A minimum of 6 year of experience in roles of increasing responsibility in the finance and accounting functions of a high-growth company, including responsibility for financial

accounting, SEC reporting and internal management reporting.

Personal Characteristics:

  • Unquestionable integrity and personal ethics.
  • Sound business judgment.
  • Ability to listen, negotiate, guide and facilitate.
  • Ability to lead and operate effectively in a team-oriented business.
  • Confident and self-aware with excellent interpersonal and communication skills, both written and verbal. Capable of quickly establishing credibility.
  • Extremely well organized and objective oriented.
  • Excellent relationship building and communication skills and the ability to work effectively in a team environment.

Work Environment:

  • HotSpot is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

To apply for this role, please email: