At HotSpot Therapeutics, we are pioneering a new approach to allosteric drug discovery by unlocking the on/off switches on proteins called "natural hotspots" to enable differentiated medicines for patients.
Humans have long aspired to imitate things we see in nature – birds inspired airplanes, the brain produced AI, and stars taught us how to create clean energy.
Within every cell, nature has engineered molecular mechanisms to combat disease. And yet, these mechanisms have never served as the inspiration for medicines… Until now.
At HotSpot, we are leading the way in targeting cellular on-off switches that are critical to a protein’s endogenous function - natural hotspots.
Our platform - Smart Allostery™ - integrates structure-function, cutting-edge pharmacology, tailored chemistry, and deep AI capabilities to systematically uncover and drug natural hotspots.
Through our proprietary platform, we are pioneering the discovery of novel allosteric medicines.
Using our Smart Allostery™ platform, we are pioneering the discovery of novel allosteric medicines that we hope will offer new ways to treat cancer and autoimmune diseases.
Our Pipeline
