New paradigm for allosteric drug discovery

Humans have long aspired to imitate things we see in nature – processes and outcomes perfected over billions of years – adapting and evolving to overcome challenges and improve life. Birds inspired airplanes, the brain produced artificial intelligence, and the stars taught us how to create clean energy.

Within every human cell, nature has engineered molecular control mechanisms to correct imbalances caused by stress and disease. And yet, never before have these mechanisms served as the inspiration for medicines. Until now.

HotSpot Therapeutics is leading the way in creating medicines that target unexploited pockets on proteins that are critical to their function - natural hotspots.

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Smart Allostery™

HotSpot Therapeutics’ platform - Smart Allostery™ - is the first that integrates machine learning, structure-function and tailored chemistry to systematically uncover and drug pockets on proteins used to control their function. HotSpot is industrializing the discovery of allosteric medicines, targeting natural hotspots to treat diseases in new ways.

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Unlocking disease biology

HotSpot has identified natural hotspots for approximately 1,500 proteins across multiple protein classes. Using its Smart Allostery™ platform, HotSpot has delivered allosteric inhibitors for transcription factors, specific kinases and E3 ligases, offering new ways to treat cancer and autoimmune diseases. HotSpot's inhibitors show exquisite selectivity, differentiated pharmacology and drug-like properties against previously undruggable targets.

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