New paradigm for
allosteric drug discovery

Humans have long aspired to imitate things we see in nature – birds inspired airplanes, the brain produced AI, and stars taught us how to create clean energy.

Within every cell, nature has engineered molecular mechanisms to combat disease. And yet, these mechanisms have never served as the inspiration for medicines… Until now.

At HotSpot, we are leading the way in targeting cellular on-off switches that are critical to a protein’s endogenous function - natural hotspots.

Our Science
spotcapture move

Smart Allostery™

Our platform - Smart Allostery™ - integrates structure-function, cutting-edge pharmacology, tailored chemistry, and deep AI capabilities to systematically uncover and drug natural hotspots.

Through our proprietary platform, we are pioneering the discovery of novel allosteric medicines.

Smart Allostery™ Platform
couple treat cancer autoimmune diseases

disease biology

Using our Smart Allostery™ platform, we are pioneering the discovery of novel allosteric medicines that we hope will offer new ways to treat cancer and autoimmune diseases.

Our Pipeline

Press releases

April 19, 2023

HotSpot Therapeutics Presents Preclinical Data from CBL-B Program at AACR Annual Meeting 2023

April 11, 2023

HotSpot Therapeutics Achieves First-In-Human Dosing with HST-1011, An Investigational Oral Small Molecule Allosteric Inhibitor of CBL-B

Latest posts

How We Balance the What and How at HotSpot

by Jonathan Montagu
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Moving Our Core Values Beyond Table Stakes

by Jonathan Montagu
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