New paradigm for
allosteric drug discovery

Humans have long aspired to imitate things we see in nature – birds inspired airplanes, the brain produced AI, and stars taught us how to create clean energy.

Within every cell, nature has engineered molecular mechanisms to combat disease. And yet, these mechanisms have never served as the inspiration for medicines… Until now.

At HotSpot, we are leading the way in targeting cellular on-off switches that are critical to a protein’s endogenous function - natural hotspots.

Our Science
spotcapture move

Smart Allostery™

Our platform - Smart Allostery™ - integrates structure-function, cutting-edge pharmacology, tailored chemistry, and deep AI capabilities to systematically uncover and drug natural hotspots.

Through our proprietary platform, we are pioneering the discovery of novel allosteric medicines.

Smart Allostery™ Platform
couple treat cancer autoimmune diseases

disease biology

Using our Smart Allostery™ platform, we are pioneering the discovery of novel allosteric medicines that we hope will offer new ways to treat cancer and autoimmune diseases.

Our Pipeline

Press releases

March 14, 2023

HotSpot Therapeutics to Present Two Poster Presentations on CBL-B Program at AACR Annual Meeting 2023

January 3, 2023

HotSpot Therapeutics Announces FDA Clearance of IND Application for HST-1011, An Investigational Small Molecule Allosteric Inhibitor of CBL-B

Latest posts

Build It and They Will Come – New Review Spotlights the Scientific Momentum Building for CBL-B Inhibition

by Jonathan Montagu
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A young girl hugging her mother from behind

Reimagining I-O with Our First Investigational Drug and a New Approach to Clinical Discovery

by Jonathan Montagu
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