Through regulatory hotspots, Nature has devised a means to selectively correct for chemical imbalances and dysregulation to restore health and proper functioning. We see this in both normal biological activity and in disease. In a select number of cases, regulatory hotspots have been successfully targeted to create important new medicines including with Acetyl CoA Carboxylase (AAC) and Bcr-abl.
HotSpot Therapeutics has designed the first and only technology platform, SpotFinder™, to identify and drug regulatory hotspots systematically across the entire proteome, including protein classes that have largely been considered undruggable.
Learn more About Our SpotFinder™ Platform