Through natural hotspots, evolution has devised a means to selectively correct for chemical imbalances and dysregulation to restore health and proper functioning. We see this in both normal biological activity and in disease. In select cases, natural hotspots have been successfully targeted to create important new medicines including those directed at Acetyl CoA Carboxylase (AAC), Bcr-abl and HIF-2a.
HotSpot has designed the first and only technology platform, Smart Allosteryâ„¢, to systematically identify and drug natural hotspots across the proteome, including protein classes largely considered undruggable.
Learn more ABOUT OUR SMART ALLOSTERY PLATFORM