February 7, 2024

Drug Discovery: Taking Inspiration from Facial Recognition

At HotSpot, we’re harnessing insights from nature by pinpointing specialized protein on/off switches, or pockets, called “natural hotspots.” To date,...

by Geraldine Harriman
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January 3, 2024

Signaling Complexes: A Ripe Opportunity for Drug Development

Signaling pathways are the intricate networks that govern cell behavior, lying at the crux of cell function. They are used...

by Jonathan Montagu
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July 11, 2023

On the Road at ASCO 2023: Key Takeaways, Observations and Reflections

The American Cancer Society for Oncology (ASCO) annual meeting is among the highlights of the clinical oncology calendar. The meeting...

by Amanda Redig
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June 1, 2023

How We Balance the What and How at HotSpot

At HotSpot, we are committed to building something we believe is truly distinctive, setting ourselves apart from our peers in...

by Jonathan Montagu
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April 28, 2023

Moving Our Core Values Beyond Table Stakes

Every company has a culture, either by design or default. From our inception in 2016, we wanted to create a...

by Jonathan Montagu
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March 1, 2023

Build It and They Will Come – New Review Spotlights the Scientific Momentum Building for CBL-B Inhibition

The phrase ‘build it and they will come’ dates all the way back to the Old Testament, and in more...

by Jonathan Montagu
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January 4, 2023

Reimagining I-O with Our First Investigational Drug and a New Approach to Clinical Discovery

HotSpot Therapeutics recently announced FDA clearance of our Investigational New Drug (IND) application for HST-1011, our small molecule allosteric inhibitor...

by Jonathan Montagu
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December 6, 2022

What Took So Long? – How Tech Has Finally Caught Up with Transcription Factors

HotSpot Therapeutics recently announced a strategic collaboration with AbbVie to develop IRF5 transcription factor inhibitors for autoimmune diseases. The following…

by Geraldine Harriman
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November 10, 2022

A Turning Point for Immuno-Oncology

Immunotherapy has been the holy grail in the fight against cancer for the last decade. For good reason, we’ve been...

by Tim Reilly
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June 21, 2022

Hacking the Human Cell – How Once ‘Un-druggable’ Proteins Became the New Frontier in Drug Development

White Hat Hackers, sometimes called “ethical hackers,” are individuals that work to find and fix security problems in a system...

by Jonathan Montagu
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April 28, 2022

A Global Community

It is in moments like this that we are reminded of the collective power of good to overcome the disenfranchised…

by Jonathan Montagu
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Cat and machine learning
March 8, 2022

Staying Human in the Age of Artificial Intelligence

No, your next doctor will not be a robot. Nor will an algorithm cure cancer. However, AI technology will absolutely...

by Ramy Farid and Jonathan Montagu
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Pieces of jigsaw puzzle and global network concept.
January 10, 2022

Making R&D ‘Smarter’ by Putting Artificial Intelligence into Practice

The pharmaceutical industry still faces unrelenting challenges across the entirety of the drug development landscape. According to Piper Sandler’s recent...

by Geraldine Harriman and Tim Reilly
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November 29, 2021

Hitting the Spot

Today marks an important point in our journey to patients as HotSpot Therapeutics announces its $100MM Series C financing.  This infusion of…

by Jonathan Montagu
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Wrecking ball destroying cancer cell
July 13, 2021

Immuno-Oncology: The Comeback Kid

Now 10 years into the golden era of immuno-oncology (I-O) following the first FDA approval of ipilimumab (anti-CTLA4) in 2011…

by Tim Reilly
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April 15, 2021

Reimagining the Workplace Post Pandemic

Returning to work following the pandemic presents an opportunity to think creatively about how to re-configure the workplace

by Jonathan Montagu
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May 20, 2020

The Business of Science

Today marks an important milestone for HotSpot Therapeutics as we announce our Series B financing, but it also marks a...

by Jonathan Montagu
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August 23, 2019

Hotspots meet DNA-encoded libraries

DNA encoded libraries (DEL) have received a lot of attention over the past few years. They’ve been hailed as “highly...

by Geraldine Harriman
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July 31, 2019

Targeting the mTORC1 Pathway With Phenotypic Screening

The conventional approach to drug discovery shines a light on specific target proteins, using an arsenal of biochemical and virtual...

by Jonathan Montagu
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June 30, 2019

Biocentury Innovations shines a new light on allostery

I was excited to participate in Allison Johnson’s recent Biocentury article reflecting on the growing interest of industry in allostery and why...

by Geraldine Harriman
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A scientist working on DNA in a test tube
May 1, 2019

Drugging the Undruggable with Allosteric Small Molecules

Advances in computational, biophysical and library technologies have driven the emergence of a new drug discovery paradigm with the power...

by Nicholas Keen
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Cute tabby cat sniffs on medicine capsules.
April 9, 2019

Cats and the future of machine learning in drug discovery

The predictions around the impact of artificial intelligence (AI) have been broad reaching but it’s clear that not everyone is...

by Jonathan Montagu
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March 11, 2019

HotSpot Frequently Asked Questions

What is a regulatory hotspot? A regulatory hotspot is a privileged allosteric site used by nature to regulate the function...

by Geraldine Harriman
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March 4, 2019

Introducing allokraft

This is an exciting time for small molecule drug discovery and soon for patients, who have been underserved by current...

by Jonathan Montagu
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January 4, 2019

Following Nature’s lead

Lately it seems that allostery is constantly in the news, especially in stories covering a series of high-profile financings by...

by Jonathan Montagu
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July 17, 2018

Hotspot Therapeutics Turns Up The Heat On Natural Allostery

Most conventional small molecule drugs engage directly with the engine of a protein’s function, aiming to often turning off an...

by Bruce Booth
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Beautiful iridescent wing of a Madagascan sunset moth (Chrysiridia rhipheus). Macro photo (Beautiful iridescent wing of a Madagascan sunset moth
June 13, 2018

Float Like A Butterfly: Agility In Biotech

In the quest towards building high-performing teams, biopharma can lift a page from the tech playbook around agile organizations.  This...

by Jonathan Montagu
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March 5, 2018

Allostery: Realizing the promise

It starts off with flu-like symptoms and progresses to a perpetual low-grade fever, excessive sweating and loss of appetite.  A...

by Jonathan Montagu
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