The pharmaceutical industry still faces unrelenting challenges across the entirety of the drug development landscape. According to Piper Sandler’s recent […]
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Hitting the Spot
Today marks an important point in our journey to patients as HotSpot Therapeutics announces its $100MM Series C financing. This infusion of capital will enable HotSpot to transition into a clinical stage company while supporting further pipeline and platform growth.
Immuno-Oncology: The Comeback Kid
Now 10 years into the golden era of immuno-oncology (I-O) following the first FDA approval of ipilimumab (anti-CTLA4) in 2011 and the seminal initial efficacy disclosure on nivolumab (anti-PD1) in 2012 (Topalian et al NEJM), we can reflect on how I-O has literally changed the lives of tens of thousands of cancer patients and their families.
Reimagining the Workplace Post Pandemic
Returning to work following the pandemic presents an opportunity to think creatively about how to re-configure the workplace
The Business of Science
Today marks an important milestone for HotSpot Therapeutics as we announce our Series B financing, but it also marks a […]
Hotspots meet DNA-encoded libraries
DNA encoded libraries (DEL) have received a lot of attention over the past few years. They’ve been hailed as “highly […]
Targeting the mTORC1 Pathway With Phenotypic Screening
The conventional approach to drug discovery shines a light on specific target proteins, using an arsenal of biochemical and virtual […]
Biocentury Innovations shines a new light on allostery
I was excited to participate in Allison Johnson’s recent Biocentury article reflecting on the growing interest of industry in allostery and why […]
Drugging the Undruggable with Allosteric Small Molecules
Advances in computational, biophysical and library technologies have driven the emergence of a new drug discovery paradigm with the power […]
