Today marks an important milestone for HotSpot Therapeutics as we announce our Series B financing, but it also marks a […]
Subscribe and get notified about new posts.
Hotspots meet DNA-encoded libraries
DNA encoded libraries (DEL) have received a lot of attention over the past few years. They’ve been hailed as “highly […]
Targeting the mTORC1 Pathway With Phenotypic Screening
The conventional approach to drug discovery shines a light on specific target proteins, using an arsenal of biochemical and virtual […]
Biocentury Innovations shines a new light on allostery
I was excited to participate in Allison Johnson’s recent Biocentury article reflecting on the growing interest of industry in allostery and why […]
Drugging the Undruggable with Allosteric Small Molecules
Advances in computational, biophysical and library technologies have driven the emergence of a new drug discovery paradigm with the power […]
Cats and the future of machine learning in drug discovery
The predictions around the impact of artificial intelligence (AI) have been broad reaching but it’s clear that not everyone is […]
HotSpot Frequently Asked Questions
What is a regulatory hotspot? A regulatory hotspot is a privileged allosteric site used by nature to regulate the function […]
Introducing allokraft
This is an exciting time for small molecule drug discovery and soon for patients, who have been underserved by current […]
Following Nature’s lead
Lately it seems that allostery is constantly in the news, especially in stories covering a series of high-profile financings by […]
