I was excited to participate in Allison Johnson’s recent Biocentury article reflecting on the growing interest of industry in allostery and why […]
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Drugging the Undruggable with Allosteric Small Molecules
Advances in computational, biophysical and library technologies have driven the emergence of a new drug discovery paradigm with the power […]
Cats and the future of machine learning in drug discovery
The predictions around the impact of artificial intelligence (AI) have been broad reaching but it’s clear that not everyone is […]
HotSpot Frequently Asked Questions
What is a regulatory hotspot? A regulatory hotspot is a privileged allosteric site used by nature to regulate the function […]
Introducing allokraft
This is an exciting time for small molecule drug discovery and soon for patients, who have been underserved by current […]
Following Nature’s lead
Lately it seems that allostery is constantly in the news, especially in stories covering a series of high-profile financings by […]
Hotspot Therapeutics Turns Up The Heat On Natural Allostery
Most conventional small molecule drugs engage directly with the engine of a protein’s function, aiming to often turning off an […]
Allostery: Realizing the promise
It starts off with flu-like symptoms and progresses to a perpetual low-grade fever, excessive sweating and loss of appetite. A […]
