February 7, 2024

Drug Discovery: Taking Inspiration from Facial Recognition

At HotSpot, we’re harnessing insights from nature by pinpointing specialized protein on/off switches, or pockets, called “natural hotspots.” To date,...

by Geraldine Harriman
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January 3, 2024

Signaling Complexes: A Ripe Opportunity for Drug Development

Signaling pathways are the intricate networks that govern cell behavior, lying at the crux of cell function. They are used...

by Jonathan Montagu
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June 1, 2023

How We Balance the What and How at HotSpot

At HotSpot, we are committed to building something we believe is truly distinctive, setting ourselves apart from our peers in...

by Jonathan Montagu
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April 28, 2023

Moving Our Core Values Beyond Table Stakes

Every company has a culture, either by design or default. From our inception in 2016, we wanted to create a...

by Jonathan Montagu
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March 1, 2023

Build It and They Will Come – New Review Spotlights the Scientific Momentum Building for CBL-B Inhibition

The phrase ‘build it and they will come’ dates all the way back to the Old Testament, and in more...

by Jonathan Montagu
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December 6, 2022

What Took So Long? – How Tech Has Finally Caught Up with Transcription Factors

HotSpot Therapeutics recently announced a strategic collaboration with AbbVie to develop IRF5 transcription factor inhibitors for autoimmune diseases. The following…

by Geraldine Harriman
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November 10, 2022

A Turning Point for Immuno-Oncology

Immunotherapy has been the holy grail in the fight against cancer for the last decade. For good reason, we’ve been...

by Tim Reilly
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June 21, 2022

Hacking the Human Cell – How Once ‘Un-druggable’ Proteins Became the New Frontier in Drug Development

White Hat Hackers, sometimes called “ethical hackers,” are individuals that work to find and fix security problems in a system...

by Jonathan Montagu
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April 28, 2022

A Global Community

It is in moments like this that we are reminded of the collective power of good to overcome the disenfranchised…

by Jonathan Montagu
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Cat and machine learning
March 8, 2022

Staying Human in the Age of Artificial Intelligence

No, your next doctor will not be a robot. Nor will an algorithm cure cancer. However, AI technology will absolutely...

by Ramy Farid and Jonathan Montagu
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