As scientists, we are accustomed to learning something new about targets (and the modulation thereof) that moves the field forward...
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At HotSpot, we’re harnessing insights from nature by pinpointing specialized protein on/off switches, or pockets, called “natural hotspots.” To date,...
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HotSpot Therapeutics recently announced a strategic collaboration with AbbVie to develop IRF5 transcription factor inhibitors for autoimmune diseases. The following…
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DNA encoded libraries (DEL) have received a lot of attention over the past few years. They’ve been hailed as “highly...
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I was excited to participate in Allison Johnson’s recent Biocentury article reflecting on the growing interest of industry in allostery and why...
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What is a regulatory hotspot? A regulatory hotspot is a privileged allosteric site used by nature to regulate the function...
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