Pieces of jigsaw puzzle and global network concept.
January 10, 2022

Making R&D ‘Smarter’ by Putting Artificial Intelligence into Practice

The pharmaceutical industry still faces unrelenting challenges across the entirety of the drug development landscape. According to Piper Sandler’s recent...

by Geraldine Harriman and Tim Reilly
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November 29, 2021

Hitting the Spot

Today marks an important point in our journey to patients as HotSpot Therapeutics announces its $100MM Series C financing.  This infusion of…

by Jonathan Montagu
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April 15, 2021

Reimagining the Workplace Post Pandemic

Returning to work following the pandemic presents an opportunity to think creatively about how to re-configure the workplace

by Jonathan Montagu
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A flat vector image of scientists around a mikroscope
May 20, 2020

The Business of Science

Today marks an important milestone for HotSpot Therapeutics as we announce our Series B financing, but it also marks a...

by Jonathan Montagu
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DNA molecules on the beautiful backdrop
August 23, 2019

Hotspots meet DNA-encoded libraries

DNA encoded libraries (DEL) have received a lot of attention over the past few years. They’ve been hailed as “highly...

by Geraldine Harriman
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July 31, 2019

Targeting the mTORC1 Pathway With Phenotypic Screening

The conventional approach to drug discovery shines a light on specific target proteins, using an arsenal of biochemical and virtual...

by Jonathan Montagu
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Vector flat style illustration depicting biomedical research concept including handmade textures.
June 30, 2019

Biocentury Innovations shines a new light on allostery

I was excited to participate in Allison Johnson’s recent Biocentury article reflecting on the growing interest of industry in allostery and why...

by Geraldine Harriman
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A scientist working on DNA in a test tube
May 1, 2019

Drugging the Undruggable with Allosteric Small Molecules

Advances in computational, biophysical and library technologies have driven the emergence of a new drug discovery paradigm with the power...

by Nicholas Keen
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Cute tabby cat sniffs on medicine capsules.
April 9, 2019

Cats and the future of machine learning in drug discovery

The predictions around the impact of artificial intelligence (AI) have been broad reaching but it’s clear that not everyone is...

by Jonathan Montagu
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March 11, 2019

HotSpot Frequently Asked Questions

What is a regulatory hotspot? A regulatory hotspot is a privileged allosteric site used by nature to regulate the function...

by Geraldine Harriman
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