Celebrating the art and science of allosteric drug discovery
I’m far from the first person to point out the prolonged market challenges that have depressed the biotech fundraising environment...
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As scientists, we are accustomed to learning something new about targets (and the modulation thereof) that moves the field forward...
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In the perpetual and never-ending race by the healthcare sector to unearth new approaches and therapeutics to address disease, one...
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HotSpot’s trip to Barcelona for the recent European Society of Medical Oncology (ESMO) Annual Meeting was no ‘European Vacation,’ but...
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As Boston’s weather has started its turn from the frigid darkness that is a northeast winter to the longer days...
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At HotSpot, we’re harnessing insights from nature by pinpointing specialized protein on/off switches, or pockets, called “natural hotspots.” To date,...
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Signaling pathways are the intricate networks that govern cell behavior, lying at the crux of cell function. They are used...
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The American Cancer Society for Oncology (ASCO) annual meeting is among the highlights of the clinical oncology calendar. The meeting...
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At HotSpot, we are committed to building something we believe is truly distinctive, setting ourselves apart from our peers in...
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Every company has a culture, either by design or default. From our inception in 2016, we wanted to create a...
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The phrase ‘build it and they will come’ dates all the way back to the Old Testament, and in more...
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HotSpot Therapeutics recently announced FDA clearance of our Investigational New Drug (IND) application for HST-1011, our small molecule allosteric inhibitor...
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HotSpot Therapeutics recently announced a strategic collaboration with AbbVie to develop IRF5 transcription factor inhibitors for autoimmune diseases. The following…
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Immunotherapy has been the holy grail in the fight against cancer for the last decade. For good reason, we’ve been...
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White Hat Hackers, sometimes called “ethical hackers,” are individuals that work to find and fix security problems in a system...
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It is in moments like this that we are reminded of the collective power of good to overcome the disenfranchised…
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No, your next doctor will not be a robot. Nor will an algorithm cure cancer. However, AI technology will absolutely...
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The pharmaceutical industry still faces unrelenting challenges across the entirety of the drug development landscape. According to Piper Sandler’s recent...
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Today marks an important point in our journey to patients as HotSpot Therapeutics announces its $100MM Series C financing. This infusion of…
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Now 10 years into the golden era of immuno-oncology (I-O) following the first FDA approval of ipilimumab (anti-CTLA4) in 2011…
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Returning to work following the pandemic presents an opportunity to think creatively about how to re-configure the workplace
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Today marks an important milestone for HotSpot Therapeutics as we announce our Series B financing, but it also marks a...
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DNA encoded libraries (DEL) have received a lot of attention over the past few years. They’ve been hailed as “highly...
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The conventional approach to drug discovery shines a light on specific target proteins, using an arsenal of biochemical and virtual...
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I was excited to participate in Allison Johnson’s recent Biocentury article reflecting on the growing interest of industry in allostery and why...
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Advances in computational, biophysical and library technologies have driven the emergence of a new drug discovery paradigm with the power...
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The predictions around the impact of artificial intelligence (AI) have been broad reaching but it’s clear that not everyone is...
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What is a regulatory hotspot? A regulatory hotspot is a privileged allosteric site used by nature to regulate the function...
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This is an exciting time for small molecule drug discovery and soon for patients, who have been underserved by current...
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Lately it seems that allostery is constantly in the news, especially in stories covering a series of high-profile financings by...
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Most conventional small molecule drugs engage directly with the engine of a protein’s function, aiming to often turning off an...
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In the quest towards building high-performing teams, biopharma can lift a page from the tech playbook around agile organizations. This...
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It starts off with flu-like symptoms and progresses to a perpetual low-grade fever, excessive sweating and loss of appetite. A...
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