October 10, 2024

ESMO Reflections: Glimmers of Hope with the Next Wave of I-O Therapies?

HotSpot’s trip to Barcelona for the recent European Society of Medical Oncology (ESMO) Annual Meeting was no ‘European Vacation,’ but...

by Jonathan Montagu
Read more
May 9, 2024

Has Spring Sprouted New Growth in Immuno-Oncology?

As Boston’s weather has started its turn from the frigid darkness that is a northeast winter to the longer days...

by Jonathan Montagu
Read more
January 3, 2024

Signaling Complexes: A Ripe Opportunity for Drug Development

Signaling pathways are the intricate networks that govern cell behavior, lying at the crux of cell function. They are used...

by Jonathan Montagu
Read more
June 1, 2023

How We Balance the What and How at HotSpot

At HotSpot, we are committed to building something we believe is truly distinctive, setting ourselves apart from our peers in...

by Jonathan Montagu
Read more
April 28, 2023

Moving Our Core Values Beyond Table Stakes

Every company has a culture, either by design or default. From our inception in 2016, we wanted to create a...

by Jonathan Montagu
Read more
March 1, 2023

Build It and They Will Come – New Review Spotlights the Scientific Momentum Building for CBL-B Inhibition

The phrase ‘build it and they will come’ dates all the way back to the Old Testament, and in more...

by Jonathan Montagu
Read more
A young girl hugging her mother from behind
January 4, 2023

Reimagining I-O with Our First Investigational Drug and a New Approach to Clinical Discovery

HotSpot Therapeutics recently announced FDA clearance of our Investigational New Drug (IND) application for HST-1011, our small molecule allosteric inhibitor...

by Jonathan Montagu
Read more
June 21, 2022

Hacking the Human Cell – How Once ‘Un-druggable’ Proteins Became the New Frontier in Drug Development

White Hat Hackers, sometimes called “ethical hackers,” are individuals that work to find and fix security problems in a system...

by Jonathan Montagu
Read more
Ukraine Berlin
April 28, 2022

A Global Community

It is in moments like this that we are reminded of the collective power of good to overcome the disenfranchised…

by Jonathan Montagu
Read more
November 29, 2021

Hitting the Spot

Today marks an important point in our journey to patients as HotSpot Therapeutics announces its $100MM Series C financing.  This infusion of…

by Jonathan Montagu
Read more