July 31, 2025

A “Complex” Solution to a “Complex” Problem? Attacking KRASG12X Colorectal Cancer Through the CBM Signalosome

As scientists, we are accustomed to learning something new about targets (and the modulation thereof) that moves the field forward...

by Geraldine Harriman
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February 5, 2025

A New Wave of Therapeutic Innovation Through Targeting Transcription Factors

In the perpetual and never-ending race by the healthcare sector to unearth new approaches and therapeutics to address disease, one...

by Jonathan Montagu
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October 10, 2024

ESMO Reflections: Glimmers of Hope with the Next Wave of I-O Therapies?

HotSpot’s trip to Barcelona for the recent European Society of Medical Oncology (ESMO) Annual Meeting was no ‘European Vacation,’ but...

by Jonathan Montagu
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May 9, 2024

Has Spring Sprouted New Growth in Immuno-Oncology?

As Boston’s weather has started its turn from the frigid darkness that is a northeast winter to the longer days...

by Jonathan Montagu
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February 7, 2024

Drug Discovery: Taking Inspiration from Facial Recognition

At HotSpot, we’re harnessing insights from nature by pinpointing specialized protein on/off switches, or pockets, called “natural hotspots.” To date,...

by Geraldine Harriman
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January 3, 2024

Signaling Complexes: A Ripe Opportunity for Drug Development

Signaling pathways are the intricate networks that govern cell behavior, lying at the crux of cell function. They are used...

by Jonathan Montagu
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July 11, 2023

On the Road at ASCO 2023: Key Takeaways, Observations and Reflections

The American Cancer Society for Oncology (ASCO) annual meeting is among the highlights of the clinical oncology calendar. The meeting...

by Amanda Redig
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June 1, 2023

How We Balance the What and How at HotSpot

At HotSpot, we are committed to building something we believe is truly distinctive, setting ourselves apart from our peers in...

by Jonathan Montagu
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March 1, 2023

Build It and They Will Come – New Review Spotlights the Scientific Momentum Building for CBL-B Inhibition

The phrase ‘build it and they will come’ dates all the way back to the Old Testament, and in more...

by Jonathan Montagu
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A young girl hugging her mother from behind
January 4, 2023

Reimagining I-O with Our First Investigational Drug and a New Approach to Clinical Discovery

HotSpot Therapeutics recently announced FDA clearance of our Investigational New Drug (IND) application for HST-1011, our small molecule allosteric inhibitor...

by Jonathan Montagu
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